In the competitive environment, service and manufacturing organizations try to improve the quality of their services and productions. In this regard, information systems are the important factors in achieving competitive advantages. But many organizations don’t know anything about the influential factors on the success of information systems. Literature suggests a number of factors, so that the impact of organizational factors and organizational learning on the success of information systems are studied in this research based on structural equation modeling. Population is Esfahan Industries and Mines Organization. After gathering information through questionnaire and analyzes it, results show that organizational factors and organizational learning influence on the Success of Information Systems in the Esfahan Industries and Mines Organization.